What the FDA labels say about taking them together
Hydrocodone and mirtazapine
Hydrocodone's FDA label of May 29, 2026 names mirtazapine in its drug interactions section; the mirtazapine label PlainMeds reads does not name hydrocodone. The hydrocodone label: “The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome.”
Check it at the source: the hydrocodone FDA label on DailyMed (effective May 29, 2026); the mirtazapine FDA label on DailyMed (effective August 6, 2025, Organon LLC).
What does the hydrocodone label say about mirtazapine?
Hydrocodone label, drug interactionsSerotonergic Drugs Clinical Impact: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome. … (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase inhibitors (those intended to treat psychiatric disorders and also others, such as …
Source: FDA drug label (Hysingla ER), Knoa Pharma LLC, effective May 29, 2026 (SPL set b7d23ac2-e776-9f62-3290-c64c2d6eb353), via openFDA; the full label on DailyMed
What does the mirtazapine label say about hydrocodone?
Mirtazapine's label (effective August 6, 2025) does not name hydrocodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (REMERON), Organon LLC, effective August 6, 2025 (SPL set 98ad1917-a094-44f5-a28f-a64a8cfcd887), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydrocodone | Mirtazapine | |
|---|---|---|
| Labeled for | Pain | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $7.95 per capsule 15 mg capsule | $0.063 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once