What the FDA labels say about taking them together
Colestipol and hydrochlorothiazide
Colestipol's FDA label of February 19, 2024 names hydrochlorothiazide in its drug interactions section, and hydrochlorothiazide's label names colestipol too. The hydrochlorothiazide label: “Cholestyramine and colestipol: Reduced absorption of thiazides Lithium: Increased lithium concentrations and lithium toxicity Antidiabetic drugs:”
Check it at the source: the colestipol FDA label on DailyMed (effective February 19, 2024, Zydus Pharmaceuticals USA Inc.); the hydrochlorothiazide FDA label on DailyMed (effective June 12, 2026, Leading Pharma, LLC).
What does the colestipol label say about hydrochlorothiazide?
Colestipol label, drug interactionsThe absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride.
Source: FDA drug label (Colestipol hydrochloride), Zydus Pharmaceuticals USA Inc., effective February 19, 2024 (SPL set 71f12e0d-373a-4867-b37c-f24d99c5ce95), via openFDA; the full label on DailyMed
What does the hydrochlorothiazide label say about colestipol?
Hydrochlorothiazide label (QPharma, Inc., December 5, 2025), drug interactionsCholestyramine and colestipol resins - Cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.
Inzirqo label (ANI Pharmaceuticals, Inc., December 16, 2025), drug interactionsCholestyramine and colestipol: Reduced absorption of thiazides (7.1) Lithium: Increased lithium concentrations and lithium toxicity (7.2) Antidiabetic drugs:
Source: FDA drug label (Hydrochlorothiazide, NDA020504), QPharma, Inc., effective December 5, 2025 (SPL set 5bacc909-6b02-4815-85ef-55fd25b1b1f7), via openFDA
Source: FDA drug label (Inzirqo, NDA219141), ANI Pharmaceuticals, Inc., effective December 16, 2025 (SPL set 41aaea48-6c1b-42c8-a96f-5923d49dc934), via openFDA
Source: FDA drug label (HYDROCHLOROTHIAZIDE), Leading Pharma, LLC, effective June 12, 2026 (SPL set 8c868894-667e-4a51-906a-838d63e420ba), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colestipol | Hydrochlorothiazide | |
|---|---|---|
| Labeled for | High cholesterol | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.658 per tablet 1 g tablet | $0.0115 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once