What the FDA labels say about taking them together
Hyaluronidase and sodium bicarbonate
Sodium bicarbonate's FDA label of August 4, 2026 names hyaluronidase in its warnings and precautions (prescription label) section; the hyaluronidase labels PlainMeds reads (2) do not name sodium bicarbonate. The sodium bicarbonate label: “Prompt elevation of the area, warmth, and local injection of lidocaine or hyaluronidase are recommended to reduce the likelihood of tissue sloughing at the site.”
Check it at the source: the hyaluronidase FDA label on DailyMed (effective February 1, 2024, Amphastar Pharmaceuticals, Inc.); the sodium bicarbonate FDA label on DailyMed (effective August 4, 2026).
What does the hyaluronidase label say about sodium bicarbonate?
Hyaluronidase's label (effective February 1, 2024) and its 1 other brand-application label do not name sodium bicarbonate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (AMPHADASE), Amphastar Pharmaceuticals, Inc., effective February 1, 2024 (SPL set 8396ea96-7cb5-4e26-87a4-90bca9c3c6dd), via openFDA; the full label on DailyMed
What does the sodium bicarbonate label say about hyaluronidase?
Sodium bicarbonate label, warnings and precautions (prescription label)Extravasation: Prompt elevation of the area, warmth, and local injection of lidocaine or hyaluronidase are recommended to reduce the likelihood of tissue sloughing at the site.
Source: FDA drug label (Sodium Bicarbonate, NDA220790), Amneal Pharmaceuticals Private Limited, effective July 9, 2026 (SPL set ac91e834-e693-43a2-829b-56793453e8cc), via openFDA
Source: FDA drug label (Sodium Bicarbonate 5 gr), TWIN MED LLC, effective August 4, 2026 (SPL set e325d899-d9a6-5adb-e053-2995a90ac861), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hyaluronidase | Sodium bicarbonate | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers, Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $53.69 per mL 150 units/mL vial | $0.154 per mL 8.4% vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once