What the FDA labels say about taking them together
Histrelin and testosterone
Histrelin's FDA label of September 25, 2025 names testosterone in its warnings and precautions section; the testosterone labels PlainMeds reads (4) do not name histrelin. The histrelin label: “WARNINGS AND PRECAUTIONS Initial Agnostic Action: Initial transient increases of estradiol and/or testosterone may cause a temporary worsening of symptoms.”
Check it at the source: the histrelin FDA label on DailyMed (effective September 25, 2025, Endo USA, Inc.); the testosterone FDA label on DailyMed (effective July 25, 2025, Azurity Pharmaceuticals, Inc.).
What does the histrelin label say about testosterone?
Histrelin label, warnings and precautionsWARNINGS AND PRECAUTIONS Initial Agnostic Action: Initial transient increases of estradiol and/or testosterone may cause a temporary worsening of symptoms ( 5.1 ).
Source: FDA drug label (SUPPRELIN LA), Endo USA, Inc., effective September 25, 2025 (SPL set d8fb000e-3cc9-4803-b71d-2cc597661977), via openFDA; the full label on DailyMed
What does the testosterone label say about histrelin?
Testosterone's label (effective July 25, 2025) and its 3 other brand-application labels do not name histrelin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (AZMIRO), Azurity Pharmaceuticals, Inc., effective July 25, 2025 (SPL set 235b5625-570d-3fba-e063-6394a90aa2d1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Histrelin | Testosterone | |
|---|---|---|
| Labeled for | n/a | Breast cancer |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $11.39 per mL 200 mg/mL |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once