What the FDA labels say about taking them together
Heparin and tenecteplase
Tenecteplase's FDA label of December 15, 2025 names heparin in its warnings and precautions section; the heparin labels PlainMeds reads (4) do not name tenecteplase. The tenecteplase label: “Should serious bleeding that is not controlled by local pressure occur, discontinue any concomitant heparin or antiplatelet agents immediately and treat appropriately.”
Check it at the source: the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC); the tenecteplase FDA label on DailyMed (effective December 15, 2025, Genentech, Inc.).
What does the heparin label say about tenecteplase?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name tenecteplase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
What does the tenecteplase label say about heparin?
Tenecteplase label, warnings and precautionsShould serious bleeding that is not controlled by local pressure occur, discontinue any concomitant heparin or antiplatelet agents immediately and treat appropriately.
Source: FDA drug label (TNKase), Genentech, Inc., effective December 15, 2025 (SPL set e647640d-c395-4b4b-a0be-1162f9c21d84), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Heparin | Tenecteplase | |
|---|---|---|
| Labeled for | Blood clots (DVT and PE), Atrial fibrillation | Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.18 per mL 5,000 unit/mL vial | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once