What the FDA labels say about taking them together
Heparin and sugammadex
Sugammadex's FDA label of March 13, 2026 names heparin in its warnings and precautions section; the heparin labels PlainMeds reads (4) do not name sugammadex. The sugammadex label: “In patients undergoing major orthopedic surgery of the lower extremity who were concomitantly treated with heparin or low molecular weight heparin for thromboprophylaxis, increases in aPTT and PT(INR) of 5.5% and 3.0% …”
Check it at the source: the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC); the sugammadex FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC).
What does the heparin label say about sugammadex?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name sugammadex in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
What does the sugammadex label say about heparin?
Sugammadex label, warnings and precautionsIn patients undergoing major orthopedic surgery of the lower extremity who were concomitantly treated with heparin or low molecular weight heparin for thromboprophylaxis, increases in aPTT and PT(INR) of 5.5% and 3.0%, respectively, were observed in the hour following BRIDION 4 mg/kg administration.
Source: FDA drug label (BRIDION), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 5171d883-fe8f-482c-97ab-40b00975b64a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Heparin | Sugammadex | |
|---|---|---|
| Labeled for | Blood clots (DVT and PE), Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.18 per mL 5,000 unit/mL vial | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once