What the FDA labels say about taking them together
Heparin and salicylic acid
Heparin's FDA label (Heparin Sodium) of April 30, 2026 names salicylic acid in its drug interactions section, and salicylic acid's label names heparin too. The heparin label: “Drugs such as NSAIDS, dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists, and others that interfere with platelet-aggregation reactions may induce bleeding and …”
Check it at the source: the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC); the salicylic acid FDA label on DailyMed (effective October 22, 2024).
What does the heparin label say about salicylic acid?
Heparin Sodium label (Fresenius Kabi USA, LLC, April 30, 2026), drug interactionsDrugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Source: FDA drug label (Heparin Sodium, NDA017029), Fresenius Kabi USA, LLC, effective April 30, 2026 (SPL set 2a173253-dfdc-4d9d-8dee-b9c13e6fa9f5), via openFDA
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
What does the salicylic acid label say about heparin?
Salicylic acid label, drug interactions (prescription label)Drug: Heparin; Description: Salicylate decreases platelet adhesiveness and interferes with hemostasis in heparin-treated patients
Source: FDA drug label (bareMinerals Blemish Rescue Skin-Clearing Loose Foundation Fair 1C), Orveon Global US LLC, effective October 22, 2024 (SPL set 139e2d26-76de-4ad3-a6e6-7465bf5987ad), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Heparin | Salicylic acid | |
|---|---|---|
| Labeled for | Blood clots (DVT and PE), Atrial fibrillation | Acne, Pain, Psoriasis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.18 per mL 5,000 unit/mL vial | $0.102 per patch Callus removers patch |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once