What the FDA labels say about taking them together
Haloperidol and nefazodone
Haloperidol's FDA label (Haloperidol Decanoate) of February 19, 2025 names nefazodone in its drug interactions section, and nefazodone's label names haloperidol too. The haloperidol label: “… Examples include: CYP3A4 inhibitors – alprazolam; itraconazole, ketoconazole, nefazodone, ritonavir.”
Check it at the source: the haloperidol FDA label on DailyMed (effective April 23, 2026, PD-Rx Pharmaceuticals, Inc.); the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.).
What does the haloperidol label say about nefazodone?
Haloperidol Decanoate label (Patriot Pharmaceuticals LLC, February 19, 2025), drug interactionsThe haloperidol plasma concentrations increased when a CYP3A4 and/or CYP2D6 inhibitor was coadministered with haloperidol. Examples include: CYP3A4 inhibitors – alprazolam; itraconazole, ketoconazole, nefazodone, ritonavir.
Source: FDA drug label (Haloperidol Decanoate, NDA018701), Patriot Pharmaceuticals LLC, effective February 19, 2025 (SPL set 9f0f42a8-5f7c-4be7-93ef-3ec225502cc6), via openFDA
Source: FDA drug label (Haloperidol), PD-Rx Pharmaceuticals, Inc., effective April 23, 2026 (SPL set 533b0b4c-cbd6-4ec0-a333-8b04b5b43a1d), via openFDA; the full label on DailyMed
What does the nefazodone label say about haloperidol?
Nefazodone label, drug interactionsHaloperidol – When a single oral 5 mg dose of haloperidol was coadministered with nefazodone (200 mg BID) at steady state, haloperidol apparent clearance decreased by 35% with no significant increase in peak haloperidol plasma concentrations or time of peak.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Haloperidol | Nefazodone | |
|---|---|---|
| Labeled for | Schizophrenia | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $15.60 per mL 100 mg/mL vial | $1.17 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once