What the FDA labels say about taking them together
Haloperidol and lithium
Haloperidol's FDA label of April 23, 2026 names lithium in its warnings section; the lithium labels PlainMeds reads (4) do not name haloperidol.
Check it at the source: the haloperidol FDA label on DailyMed (effective April 23, 2026, PD-Rx Pharmaceuticals, Inc.); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the haloperidol label say about lithium?
Haloperidol label, warningsCombined Use of Haloperidol and Lithium An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN, and FBS) followed by irreversible brain damage has occurred in a few patients treated with lithium plus haloperidol.
Source: FDA drug label (Haloperidol), PD-Rx Pharmaceuticals, Inc., effective April 23, 2026 (SPL set 533b0b4c-cbd6-4ec0-a333-8b04b5b43a1d), via openFDA; the full label on DailyMed
What does the lithium label say about haloperidol?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name haloperidol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Haloperidol | Lithium | |
|---|---|---|
| Labeled for | Schizophrenia | Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $15.60 per mL 100 mg/mL vial | $0.104 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once