What the FDA labels say about taking them together
Haloperidol and imipramine
Haloperidol's FDA label (Haloperidol Decanoate) of February 19, 2025 names imipramine in its drug interactions section; the imipramine label PlainMeds reads does not name haloperidol. The haloperidol label: “Plasma concentrations of CYP2D6 substrates may increase when they are co-administered with haloperidol.”
Check it at the source: the haloperidol FDA label on DailyMed (effective April 23, 2026, PD-Rx Pharmaceuticals, Inc.); the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC).
What does the haloperidol label say about imipramine?
Haloperidol Decanoate label (Patriot Pharmaceuticals LLC, February 19, 2025), drug interactionsPlasma concentrations of CYP2D6 substrates (e, g. tricyclic antidepressants such as desipramine or imipramine) may increase when they are co-administered with haloperidol.
Source: FDA drug label (Haloperidol Decanoate, NDA018701), Patriot Pharmaceuticals LLC, effective February 19, 2025 (SPL set 9f0f42a8-5f7c-4be7-93ef-3ec225502cc6), via openFDA
Source: FDA drug label (Haloperidol), PD-Rx Pharmaceuticals, Inc., effective April 23, 2026 (SPL set 533b0b4c-cbd6-4ec0-a333-8b04b5b43a1d), via openFDA; the full label on DailyMed
What does the imipramine label say about haloperidol?
Imipramine's label (effective August 11, 2026) does not name haloperidol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Haloperidol | Imipramine | |
|---|---|---|
| Labeled for | Schizophrenia | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $15.60 per mL 100 mg/mL vial | $0.0698 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once