Golimumab and Methotrexate Interaction
Drug interaction information between Golimumab and Methotrexate.
Golimumab and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Golimumab and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Methotrexate makes golimumab last longer in your body by slowing its removal and stopping your immune system from attacking the drug.
FDA Label Information
7.1 Methotrexate SIMPONI ARIA should be used with MTX for the treatment of RA [see Clinical Studies (14.1) ] . Following IV administration, concomitant administration of methotrexate decreases the clearance of SIMPONI ARIA by approximately 9% based on population pharmacokinetics (PK) analysis. In addition, concomitant administration of methotrexate decreases the SIMPONI ARIA clearance by reducing the development of antibodies to golimumab.
Golimumab Also Interacts With
- Abatacept moderate
- Warfarin minor
- Cyclosporine minor
- Theophylline minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Golimumab + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Golimumab's 5. In the minor band specifically: Golimumab has 4 (also Warfarin, Cyclosporine, Theophylline); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Golimumab and Methotrexate?
Methotrexate makes golimumab last longer in your body by slowing its removal and stopping your immune system from attacking the drug.
Methotrexate's labeled portfolio outnumbers Golimumab
SPL source-record counts only. This page's band is minor · classes on file: Golimumab (TNF-Alpha Inhibitor (Biologic)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Golimumab
- Warfarin
- Cyclosporine
- Theophylline
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.