Golimumab and Cyclosporine Interaction
Drug interaction information between Golimumab and Cyclosporine.
Golimumab and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Golimumab and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Golimumab can change how your liver breaks down cyclosporine, which might change the amount of medicine in your blood.
FDA Label Information
Upon initiation or discontinuation of SIMPONI ARIA in patients being treated with CYP450 substrates with a narrow therapeutic index, monitoring of the effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) is recommended and the individual dose of the drug product may be adjusted as needed.
Golimumab Also Interacts With
- Abatacept moderate
- Warfarin minor
- Methotrexate minor
- Theophylline minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Golimumab + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Golimumab's 5. In the minor band specifically: Golimumab has 4 (also Warfarin, Methotrexate, Theophylline); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Golimumab and Cyclosporine?
Golimumab can change how your liver breaks down cyclosporine, which might change the amount of medicine in your blood.
Cyclosporine carries more major-labeled pairs than Golimumab
SPL source-record counts only. This page's band is minor · classes on file: Golimumab (TNF-Alpha Inhibitor (Biologic)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Golimumab's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Golimumab
- Warfarin
- Methotrexate
- Theophylline
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.