What the FDA labels say about taking them together
Glyburide and trandolapril/verapamil
Trandolapril/verapamil's FDA label of January 29, 2026 names glyburide in its drug interactions section; glyburide's label does not name trandolapril/verapamil itself but warns about its class (ACE inhibitors, Calcium channel blockers). The trandolapril/verapamil label: “There have been reports that verapamil may elevate the concentrations of the oral anti-diabetic glyburide.”
Check it at the source: the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc); the trandolapril/verapamil FDA label on DailyMed (effective January 29, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the glyburide label say about trandolapril/verapamil?
Glyburide's label does not name trandolapril/verapamil itself; it warns about its class (ACE inhibitors, Calcium channel blockers):
Glyburide label, drug interactionsDrug Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed
What does the trandolapril/verapamil label say about glyburide?
Trandolapril/verapamil label, drug interactionsThere have been reports that verapamil may elevate the concentrations of the oral anti-diabetic glyburide.
Source: FDA drug label (Trandolapril and Verapamil Hydrochloride), Glenmark Pharmaceuticals Inc., USA, effective January 29, 2026 (SPL set 39bad727-af4c-4d20-933b-7f287e88099a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glyburide | Trandolapril/verapamil | |
|---|---|---|
| Labeled for | Type 2 diabetes | High blood pressure |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0643 per tablet 5 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once