What the FDA labels say about taking them together
Glyburide and stiripentol
Stiripentol's FDA label of April 27, 2026 names glyburide in its drug interactions section; the glyburide label PlainMeds reads does not name stiripentol. The stiripentol label: “Because of potential inhibition of enzyme/transporter activity, consider a reduction in dosage of substrates of CYP2C8, CYP2C19, P-gp (e.g., carbamazepine), and BCRP, if adverse reactions are experienced when …”
Check it at the source: the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc); the stiripentol FDA label on DailyMed (effective April 27, 2026, BIOCODEX, INC.).
What does the glyburide label say about stiripentol?
Glyburide's label (effective July 1, 2021) does not name stiripentol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed
What does the stiripentol label say about glyburide?
Stiripentol label, drug interactionsBecause of potential inhibition of enzyme/transporter activity, consider a reduction in dosage of substrates of CYP2C8, CYP2C19 (e.g., diazepam, clopidogrel), P-gp (e.g., carbamazepine), and BCRP (e.g., methotrexate, prazosin, glyburide), if adverse reactions are experienced when administered concomitantly with DIACOMIT.
Source: FDA drug label (Diacomit), BIOCODEX, INC., effective April 27, 2026 (SPL set 58304ba8-9779-4658-811e-94ffe08c3f16), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glyburide | Stiripentol | |
|---|---|---|
| Labeled for | Type 2 diabetes | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0643 per tablet 5 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once