What the FDA labels say about taking them together
Glucarpidase and leucovorin
Glucarpidase's FDA label of November 27, 2024 names leucovorin in its drug interactions section, and leucovorin's label names glucarpidase too. The leucovorin label: “Glucarpidase can decrease leucovorin concentrations, which may decrease the effect of leucovorin rescue.”
Check it at the source: the glucarpidase FDA label on DailyMed (effective November 27, 2024, BTG International Inc.); the leucovorin FDA label on DailyMed (effective March 19, 2025, Meitheal Pharmaceuticals Inc.).
What does the glucarpidase label say about leucovorin?
Glucarpidase label, drug interactionsDRUG INTERACTIONS 7.1 Effects of VORAXAZE on Leucovorin VORAXAZE can decrease leucovorin concentration, which may decrease the effect of leucovorin rescue unless leucovorin is dosed as recommended [see Dosage and Administration ( 2.2 ), Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Voraxaze), BTG International Inc., effective November 27, 2024 (SPL set acaef5a6-b740-40e3-8ffe-74a75c74745c), via openFDA; the full label on DailyMed
What does the leucovorin label say about glucarpidase?
Vykoura label (Avyxa Pharma, LLC, March 12, 2026), drug interactionsGlucarpidase can decrease leucovorin concentrations, which may decrease the effect of leucovorin rescue.
Source: FDA drug label (Vykoura, NDA220406), Avyxa Pharma, LLC, effective March 12, 2026 (SPL set d122b875-435e-4e00-b945-7a0546df95c2), via openFDA
Source: FDA drug label (leucovorin calcium), Meitheal Pharmaceuticals Inc., effective March 19, 2025 (SPL set 9df20901-6980-4d4e-89ec-40f3c1f91852), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glucarpidase | Leucovorin | |
|---|---|---|
| Labeled for | n/a | Colorectal cancer |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.330 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once