What the FDA labels say about taking them together
Glucagon and paltusotine
Paltusotine's FDA label of September 16, 2025 names glucagon in its warnings and precautions section; the glucagon labels PlainMeds reads (4) do not name paltusotine. The paltusotine label: “Hyperglycemia and Hypoglycemia PALSONIFY may alter the balance between the counter-regulatory hormones, insulin, glucagon, and growth hormone, which may result in hypoglycemia, hyperglycemia, or diabetes mellitus.”
Check it at the source: the glucagon FDA label on DailyMed (effective August 11, 2026, Amphastar Pharmaceuticals, Inc.); the paltusotine FDA label on DailyMed (effective September 16, 2025, Crinetics Pharmaceuticals, Inc.).
What does the glucagon label say about paltusotine?
Glucagon's label (effective August 11, 2026) and its 3 other brand-application labels do not name paltusotine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Glucagon), Amphastar Pharmaceuticals, Inc., effective August 11, 2026 (SPL set 8cc40354-b5ac-45b6-a211-93b44444f2a3), via openFDA; the full label on DailyMed
What does the paltusotine label say about glucagon?
Paltusotine label, warnings and precautionsHyperglycemia and Hypoglycemia PALSONIFY may alter the balance between the counter-regulatory hormones, insulin, glucagon, and growth hormone, which may result in hypoglycemia, hyperglycemia, or diabetes mellitus.
Source: FDA drug label (PALSONIFY), Crinetics Pharmaceuticals, Inc., effective September 16, 2025 (SPL set 8a6d2ce0-a621-4ee7-983c-977cd948ff4d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glucagon | Paltusotine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $154.20 per kit 1 mg emergency kit | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once