What the FDA labels say about taking them together
Glecaprevir/pibrentasvir and pravastatin
Glecaprevir/pibrentasvir's FDA label of June 25, 2025 names pravastatin in its drug interactions section; the pravastatin label PlainMeds reads does not name glecaprevir/pibrentasvir. The glecaprevir/pibrentasvir label: “Coadministration may increase the concentration of pravastatin. Increased statin concentrations may increase the risk of myopathy, including rhabdomyolysis. …”
Check it at the source: the glecaprevir/pibrentasvir FDA label on DailyMed (effective June 25, 2025, AbbVie Inc.); the pravastatin FDA label on DailyMed (effective July 31, 2026, Apotex Corp.).
What does the glecaprevir/pibrentasvir label say about pravastatin?
Glecaprevir/pibrentasvir label, drug interactionsConcomitant Drug Class/Drug Name: Pravastatin; Effect on Concentration: ↑ pravastatin; Clinical Comments: Coadministration may increase the concentration of pravastatin. Increased statin concentrations may increase the risk of myopathy, including rhabdomyolysis. Reduce pravastatin dose by 50% when coadministered with MAVYRET.
Source: FDA drug label (Mavyret), AbbVie Inc., effective June 25, 2025 (SPL set 7bf99777-0401-9095-8645-16c6e907fcc0), via openFDA; the full label on DailyMed
What does the pravastatin label say about glecaprevir/pibrentasvir?
Pravastatin's label (effective July 31, 2026) does not name glecaprevir/pibrentasvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PRAVASTATIN SODIUM), Apotex Corp., effective July 31, 2026 (SPL set dcf45e4f-b46e-6fbb-b67a-2ff619ab1780), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glecaprevir/pibrentasvir | Pravastatin | |
|---|---|---|
| Labeled for | Hepatitis C | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $152.98 per tablet 100-40 mg tablet | $0.058 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once