What the FDA labels say about taking them together
Gemfibrozil and resmetirom
Resmetirom's FDA label of July 29, 2026 names gemfibrozil in its drug interactions section; the gemfibrozil labels PlainMeds reads (2) do not name resmetirom. The resmetirom label: “Intervention; Concomitant use of REZDIFFRA with strong CYP2C8 inhibitors (e.g., gemfibrozil) is not recommended. Reduce REZDIFFRA dosage if used concomitantly with a moderate CYP2C8 inhibitor (e.g., clopidogrel) [ see ].”
Check it at the source: the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC); the resmetirom FDA label on DailyMed (effective July 29, 2026, Madrigal Pharmaceuticals, Inc.).
What does the gemfibrozil label say about resmetirom?
Gemfibrozil's label (effective April 10, 2026) and its 1 other brand-application label do not name resmetirom in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
What does the resmetirom label say about gemfibrozil?
Resmetirom label, drug interactionsIntervention; Concomitant use of REZDIFFRA with strong CYP2C8 inhibitors (e.g., gemfibrozil) is not recommended. Reduce REZDIFFRA dosage if used concomitantly with a moderate CYP2C8 inhibitor (e.g., clopidogrel) [ see ].
Source: FDA drug label (REZDIFFRA), Madrigal Pharmaceuticals, Inc., effective July 29, 2026 (SPL set e67ea09f-a840-439c-86c8-f98585f978b2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gemfibrozil | Resmetirom | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.104 per tablet 600 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once