What the FDA labels say about taking them together
Gemfibrozil and loperamide
Gemfibrozil's FDA label of April 10, 2026 names loperamide in its drug interactions section, and loperamide's label names gemfibrozil too. The gemfibrozil label: “(C) CYP2C8 Substrates: Gemfibrozil is a strong inhibitor of CYP2C8 and may increase exposure of drugs mainly metabolized by CYP2C8.”
Check it at the source: the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC); the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited).
What does the gemfibrozil label say about loperamide?
Gemfibrozil label, drug interactions(C) CYP2C8 Substrates: Gemfibrozil is a strong inhibitor of CYP2C8 and may increase exposure of drugs mainly metabolized by CYP2C8 (e.g., dabrafenib, enzalutamide, loperamide, montelukast, paclitaxel, pioglitazone, rosiglitazone).
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
What does the loperamide label say about gemfibrozil?
Loperamide label, drug interactions (prescription label)DRUG INTERACTIONS Effects of Other Drugs on Loperamide Concomitant use of Loperamide Hydrochloride Capsules with inhibitors of CYP3A4 (e.g., itraconazole) or CYP2C8 (e.g., gemfibrozil) or inhibitors of P-glycoprotein (e.g., quinidine, ritonavir) can increase exposure to loperamide.
Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gemfibrozil | Loperamide | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease | Diarrhea |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.104 per tablet 600 mg tablet | $0.0549 per capsule 2 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once