What the FDA labels say about taking them together
Gemfibrozil and itraconazole
Gemfibrozil's FDA label of April 10, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name gemfibrozil. The gemfibrozil label: “In the same study, gemfibrozil + itraconazole resulted in a 19.4- (range 12.9- to 24.7-fold) higher repaglinide AUC and a 70.4-fold higher repaglinide plasma concentration 7 hours after the dose.”
Check it at the source: the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the gemfibrozil label say about itraconazole?
Gemfibrozil label, drug interactionsIn the same study, gemfibrozil (600 mg twice daily for 3 days) + itraconazole (200 mg in the morning and 100 mg in the evening at Day 1, then 100 mg twice daily at Day 2-3) resulted in a 19.4- (range 12.9- to 24.7-fold) higher repaglinide AUC and a 70.4-fold (range 42.9- to 119.2-fold) higher repaglinide plasma concentration 7 hours after the dose.
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
What does the itraconazole label say about gemfibrozil?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name gemfibrozil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gemfibrozil | Itraconazole | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease | Fungal infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.104 per tablet 600 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once