What the FDA labels say about taking them together
Gemfibrozil and iptacopan
Iptacopan's FDA label of July 16, 2026 names gemfibrozil in its drug interactions section; the gemfibrozil labels PlainMeds reads (2) do not name iptacopan. The iptacopan label: “Monitor for loss of efficacy. Strong CYP2C8 inhibitors (e.g., gemfibrozil): May increase iptacopan exposure.”
Check it at the source: the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC); the iptacopan FDA label on DailyMed (effective July 16, 2026, Novartis Pharmaceuticals Corporation).
What does the gemfibrozil label say about iptacopan?
Gemfibrozil's label (effective April 10, 2026) and its 1 other brand-application label do not name iptacopan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
What does the iptacopan label say about gemfibrozil?
Iptacopan label, drug interactionsMonitor for loss of efficacy. ( 7.1 ) Strong CYP2C8 inhibitors (e.g., gemfibrozil): May increase iptacopan exposure.
Source: FDA drug label (FABHALTA), Novartis Pharmaceuticals Corporation, effective July 16, 2026 (SPL set a76b5845-6e21-4d3b-ad07-cd8df1b60bee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gemfibrozil | Iptacopan | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.104 per tablet 600 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once