What the FDA labels say about taking them together
Gabapentin enacarbil and morphine
Gabapentin enacarbil's FDA label of April 28, 2025 names morphine in its drug interactions section; the morphine labels PlainMeds reads (4) do not name gabapentin enacarbil. The gabapentin enacarbil label: “HORIZANT taken in conjunction with morphine causes increased somnolence/sedation, dizziness, and nausea when compared with either drug alone.”
Check it at the source: the gabapentin enacarbil FDA label on DailyMed (effective April 28, 2025, Azurity Pharmaceuticals, Inc. (formerly Arbor Pharmaceuticals)); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the gabapentin enacarbil label say about morphine?
Gabapentin enacarbil label, drug interactionsHORIZANT taken in conjunction with morphine causes increased somnolence/sedation, dizziness, and nausea when compared with either drug alone [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Horizant), Azurity Pharmaceuticals, Inc. (formerly Arbor Pharmaceuticals), effective April 28, 2025 (SPL set 4c486fc7-c8c4-4c6c-b30c-366dabaeaadd), via openFDA; the full label on DailyMed
What does the morphine label say about gabapentin enacarbil?
Morphine's label (effective July 13, 2026) and its 3 other brand-application labels do not name gabapentin enacarbil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gabapentin enacarbil | Morphine | |
|---|---|---|
| Labeled for | Nerve pain and fibromyalgia | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $17.93 per tablet 300 mg tablet | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once