What the FDA labels say about taking them together
Gabapentin and sufentanil
Sufentanil's FDA label of June 1, 2026 names gabapentin in its drug interactions section; gabapentin's label does not name sufentanil itself but warns about its class (Opioids (opioid agonists)).
Check it at the source: the gabapentin FDA label on DailyMed (effective May 12, 2026, Viatris Specialty LLC); the sufentanil FDA label on DailyMed (effective June 1, 2026, Hospira, Inc.).
What does the gabapentin label say about sufentanil?
Gabapentin's label does not name sufentanil itself; it warns about its class (Opioids (opioid agonists)):
Gabapentin label, warnings and precautionsThere is evidence from case reports, human studies, and animal studies associating gabapentin with serious, life-threatening, or fatal respiratory depression when coadministered with CNS depressants, including opioids, or in the setting of underlying respiratory impairment.
Gabapentin label, warnings and precautionsThere is evidence from case reports, human studies, and animal studies associating gabapentin with serious, life-threatening, or fatal respiratory depression when co-administrated with central nervous system (CNS) depressants, including opioids, or in the setting of underlying respiratory impairment.
Source: FDA drug label (Neurontin), Viatris Specialty LLC, effective May 12, 2026 (SPL set 97935fd9-1d4a-43b6-a5d9-de994591187b), via openFDA; the full label on DailyMed
What does the sufentanil label say about gabapentin?
Sufentanil label, drug interactionsBenzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Sufentanil label, warnings and precautionsProfound sedation, respiratory depression, coma, and death may result from concomitant use of Sufentanil Citrate Injection with benzodiazepines and/or other CNS depressants, including alcohol (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids).
Source: FDA drug label (Sufentanil Citrate), Hospira, Inc., effective June 1, 2026 (SPL set 20293943-46ff-4345-1aa4-929b4e017a25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gabapentin | Sufentanil | |
|---|---|---|
| Labeled for | Nerve pain and fibromyalgia, Seizures and epilepsy | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0218 per capsule 100 mg capsule | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once