What the FDA labels say about taking them together
Gabapentin and oxymorphone
Oxymorphone's FDA label of June 29, 2026 names gabapentin in its drug interactions section; gabapentin's label does not name oxymorphone itself but warns about its class (Opioids (opioid agonists)).
Check it at the source: the gabapentin FDA label on DailyMed (effective May 12, 2026, Viatris Specialty LLC); the oxymorphone FDA label on DailyMed (effective June 29, 2026, Aurolife Pharma, LLC).
What does the gabapentin label say about oxymorphone?
Gabapentin's label does not name oxymorphone itself; it warns about its class (Opioids (opioid agonists)):
Gabapentin label, warnings and precautionsThere is evidence from case reports, human studies, and animal studies associating gabapentin with serious, life-threatening, or fatal respiratory depression when coadministered with CNS depressants, including opioids, or in the setting of underlying respiratory impairment.
Gabapentin label, warnings and precautionsThere is evidence from case reports, human studies, and animal studies associating gabapentin with serious, life-threatening, or fatal respiratory depression when co-administrated with central nervous system (CNS) depressants, including opioids, or in the setting of underlying respiratory impairment.
Source: FDA drug label (Neurontin), Viatris Specialty LLC, effective May 12, 2026 (SPL set 97935fd9-1d4a-43b6-a5d9-de994591187b), via openFDA; the full label on DailyMed
What does the oxymorphone label say about gabapentin?
Oxymorphone label, drug interactionsExamples; Benzodiazepines and other sedatives/hypnotics, anxiolytics tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Oxymorphone label, warnings and precautionsProfound sedation, respiratory depression, coma, and death may result from the concomitant use of oxymorphone hydrochloride tablets with benzodiazepines and/or other CNS depressants, including alcohol (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [ gabapentin or pregabalin] other opioid.
Source: FDA drug label (Oxymorphone Hydrochloride), Aurolife Pharma, LLC, effective June 29, 2026 (SPL set 22c7652a-aa16-4fa8-89d9-517e69059068), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gabapentin | Oxymorphone | |
|---|---|---|
| Labeled for | Nerve pain and fibromyalgia, Seizures and epilepsy | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0218 per capsule 100 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once