What the FDA labels say about taking them together
Gabapentin and hydrocodone
Gabapentin's FDA label of May 12, 2026 names hydrocodone in its drug interactions section, and hydrocodone's label names gabapentin too. The hydrocodone label: “Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.”
Check it at the source: the gabapentin FDA label on DailyMed (effective May 12, 2026, Viatris Specialty LLC); the hydrocodone FDA label on DailyMed (effective May 29, 2026).
What does the gabapentin label say about hydrocodone?
Gabapentin label, drug interactionsHydrocodone Coadministration of NEURONTIN with hydrocodone decreases hydrocodone exposure [see Clinical Pharmacology (12.3) ].
Gralise label (Almatica Pharma LLC, June 30, 2026), drug interactionsAn increase in gabapentin AUC values have been reported when administered with hydrocodone. ( 7.6 ) An increase in gabapentin AUC values have been reported when administered with morphine. ( 7.7 ) An antacid containing aluminum hydroxide and magnesium hydroxide reduced the bioavailability of gabapentin immediate release by about approximately 20%, but by only 5% when gabapentin was taken 2 hours after antacids.
Source: FDA drug label (Gralise, NDA022544), Almatica Pharma LLC, effective June 30, 2026 (SPL set 466273b1-c9fc-3930-c94b-aa11394d5140), via openFDA
Source: FDA drug label (Gabapentin, NDA021129), Mylan Pharmaceuticals Inc., effective April 12, 2025 (SPL set cff7de45-148b-4e96-88fd-6052bf75b5f7), via openFDA
Source: FDA drug label (Neurontin), Viatris Specialty LLC, effective May 12, 2026 (SPL set 97935fd9-1d4a-43b6-a5d9-de994591187b), via openFDA; the full label on DailyMed
What does the hydrocodone label say about gabapentin?
Hydrocodone label, drug interactionsBenzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death. … sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Hydrocodone label, warnings and precautionsUse with Benzodiazepines or Other CNS Depressants Profound sedation, respiratory depression, coma, and death may result from the concomitant use of HYSINGLA ER with benzodiazepines and/or other CNS depressants, including alcohol (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids).
Source: FDA drug label (Hysingla ER), Knoa Pharma LLC, effective May 29, 2026 (SPL set b7d23ac2-e776-9f62-3290-c64c2d6eb353), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gabapentin | Hydrocodone | |
|---|---|---|
| Labeled for | Nerve pain and fibromyalgia, Seizures and epilepsy | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0218 per capsule 100 mg capsule | $7.95 per capsule 15 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once