What the FDA labels say about taking them together
Cimetidine and gabapentin
Gabapentin's FDA label of May 12, 2026 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name gabapentin. The gabapentin label: “This decrease in excretion of gabapentin by cimetidine is not expected to be of clinical importance.”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the gabapentin FDA label on DailyMed (effective May 12, 2026, Viatris Specialty LLC).
What does the cimetidine label say about gabapentin?
Cimetidine's label (effective July 15, 2026) does not name gabapentin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the gabapentin label say about cimetidine?
Gabapentin label, drug interactionsThis decrease in excretion of gabapentin by cimetidine is not expected to be of clinical importance.
Gralise label (Almatica Pharma LLC, June 30, 2026), drug interactionsCimetidine Cimetidine 300 mg decreased the apparent oral clearance of gabapentin by 14% and creatinine clearance by 10%.
Source: FDA drug label (Gralise, NDA022544), Almatica Pharma LLC, effective June 30, 2026 (SPL set 466273b1-c9fc-3930-c94b-aa11394d5140), via openFDA
Source: FDA drug label (Neurontin), Viatris Specialty LLC, effective May 12, 2026 (SPL set 97935fd9-1d4a-43b6-a5d9-de994591187b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Gabapentin | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Nerve pain and fibromyalgia, Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $0.0218 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once