What the FDA labels say about taking them together
Fostemsavir and simvastatin
Fostemsavir's FDA label of February 13, 2024 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name fostemsavir. The fostemsavir label: “Use the lowest possible starting dose for statins and monitor for statin-associated adverse events.”
Check it at the source: the fostemsavir FDA label on DailyMed (effective February 13, 2024, ViiV Healthcare Company); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the fostemsavir label say about simvastatin?
Fostemsavir label, drug interactionsConcomitant Drug Class/Drug Name: Statins: Rosuvastatin b Atorvastatin Fluvastatin Pitavastatin Simvastatin; Effect on Concentration of Temsavir and/or Concomitant Drug: ↑Rosuvastatin ↑Atorvastatin ↑Fluvastatin ↑Pitavastatin ↑Simvastatin; Clinical Comment: Use the lowest possible starting dose for statins and monitor for statin-associated adverse events.
Source: FDA drug label (Rukobia), ViiV Healthcare Company, effective February 13, 2024 (SPL set a21006b7-6d6f-4f06-81b4-17978756452b), via openFDA; the full label on DailyMed
What does the simvastatin label say about fostemsavir?
Simvastatin's label (effective March 28, 2025) does not name fostemsavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fostemsavir | Simvastatin | |
|---|---|---|
| Labeled for | HIV | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $156.84 per tablet 600 mg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once