What the FDA labels say about taking them together
Fostemsavir and mitotane
Fostemsavir's FDA label of February 13, 2024 names mitotane in its contraindications section; the mitotane label PlainMeds reads does not name fostemsavir. The fostemsavir label: “Coadministration is contraindicated due to potential for loss of therapeutic effect to RUKOBIA.”
Check it at the source: the fostemsavir FDA label on DailyMed (effective February 13, 2024, ViiV Healthcare Company); the mitotane FDA label on DailyMed (effective March 3, 2026, ESTEVE PHARMACEUTICALS, S.A.).
What does the fostemsavir label say about mitotane?
Fostemsavir label, contraindicationsMitotane o Herbal product: St John’s wort ( Hypericum perforatum )
Fostemsavir label, drug interactionsConcomitant Drug Class/Drug Name: Antineoplastic: Mitotane; Effect on Concentration of Temsavir and/or Concomitant Drug: ↓Temsavir; Clinical Comment: Coadministration is contraindicated due to potential for loss of therapeutic effect to RUKOBIA [see Contraindications ()].
Source: FDA drug label (Rukobia), ViiV Healthcare Company, effective February 13, 2024 (SPL set a21006b7-6d6f-4f06-81b4-17978756452b), via openFDA; the full label on DailyMed
What does the mitotane label say about fostemsavir?
Mitotane's label (effective March 3, 2026) does not name fostemsavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lysodren), ESTEVE PHARMACEUTICALS, S.A., effective March 3, 2026 (SPL set 4046a224-8832-daa2-e063-6294a90a11d7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fostemsavir | Mitotane | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $156.84 per tablet 600 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once