What the FDA labels say about taking them together
Fosphenytoin and praziquantel
Fosphenytoin's FDA label of May 18, 2025 names praziquantel in its drug interactions section; the praziquantel label PlainMeds reads does not name fosphenytoin. The fosphenytoin label: “Interacting Agent: Other; Examples: Albendazole, chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine”
Check it at the source: the fosphenytoin FDA label on DailyMed (effective May 18, 2025, Pfizer Laboratories Div Pfizer Inc); the praziquantel FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the fosphenytoin label say about praziquantel?
Fosphenytoin label, drug interactionsInteracting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine
Source: FDA drug label (CEREBYX), NDA020450 (Parke Davis), as published by Pfizer Laboratories Div Pfizer Inc, effective May 18, 2025 (SPL set de5a6711-4abb-4c3d-a18b-266b094ace11), via openFDA; the full label on DailyMed
What does the praziquantel label say about fosphenytoin?
Praziquantel's label (effective March 2, 2026) does not name fosphenytoin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Biltricide), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 34ce1cdd-648e-4f1e-8512-bf3d4cc22eb9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosphenytoin | Praziquantel | |
|---|---|---|
| Labeled for | Seizures and epilepsy | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $53.25 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once