What the FDA labels say about taking them together
Fosinopril/hydrochlorothiazide and magnesium hydroxide
Fosinopril/hydrochlorothiazide's FDA label of April 28, 2024 names magnesium hydroxide in its drug interactions section; the magnesium hydroxide label PlainMeds reads does not name fosinopril/hydrochlorothiazide. The fosinopril/hydrochlorothiazide label: “Antacids In a clinical pharmacology study, serum levels and urinary excretion of fosinoprilat were reduced when fosinopril was coadministered with an antacid suggesting that antacids may impair absorption of fosinopril.”
Check it at the source: the fosinopril/hydrochlorothiazide FDA label on DailyMed (effective April 28, 2024, Aurobindo Pharma Limited); the magnesium hydroxide FDA label on DailyMed (effective August 21, 2026).
What does the fosinopril/hydrochlorothiazide label say about magnesium hydroxide?
Fosinopril/hydrochlorothiazide label, drug interactionsAntacids In a clinical pharmacology study, serum levels and urinary excretion of fosinoprilat were reduced when fosinopril was coadministered with an antacid (aluminum hydroxide, magnesium hydroxide, and simethicone) suggesting that antacids may impair absorption of fosinopril.
Source: FDA drug label (Fosinopril Sodium and Hydrochlorothiazide), Aurobindo Pharma Limited, effective April 28, 2024 (SPL set 35019655-9a30-4305-a262-936ad0e73071), via openFDA; the full label on DailyMed
What does the magnesium hydroxide label say about fosinopril/hydrochlorothiazide?
Magnesium hydroxide's label (effective August 21, 2026) does not name fosinopril/hydrochlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (MiraFAST soft chews), Bayer HealthCare LLC., effective August 21, 2026 (SPL set 2cee67dd-b71f-32b8-e063-6394a90ae864), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosinopril/hydrochlorothiazide | Magnesium hydroxide | |
|---|---|---|
| Labeled for | High blood pressure | Constipation, Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.634 per tablet 10-12.5 mg tablet | $0.0095 per mL Milk of magnesia suspension |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once