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What the FDA labels say about taking them together

Foscarbidopa/foslevodopa and risperidone

Foscarbidopa/foslevodopa's FDA label of March 19, 2026 names risperidone in its drug interactions section; the risperidone labels PlainMeds reads (4) do not name foscarbidopa/foslevodopa. The foscarbidopa/foslevodopa label: “Antagonists and Isoniazid Dopamine D2 receptor antagonists and isoniazid may reduce the effectiveness of foslevodopa.”

Check it at the source: the foscarbidopa/foslevodopa FDA label on DailyMed (effective March 19, 2026, AbbVie Inc.); the risperidone FDA label on DailyMed (effective May 28, 2026, Janssen Pharmaceuticals, Inc.).

What does the foscarbidopa/foslevodopa label say about risperidone?

Foscarbidopa/foslevodopa label, drug interactions

Antagonists and Isoniazid Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone, metoclopramide, papaverine) and isoniazid may reduce the effectiveness of foslevodopa.

Source: FDA drug label (Vyalev), AbbVie Inc., effective March 19, 2026 (SPL set 28e806e4-951c-40a9-9f0c-d0929caf054c), via openFDA; the full label on DailyMed

What does the risperidone label say about foscarbidopa/foslevodopa?

Risperidone's label (effective May 28, 2026) and its 3 other brand-application labels do not name foscarbidopa/foslevodopa in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (RISPERDAL), Janssen Pharmaceuticals, Inc., effective May 28, 2026 (SPL set 7e117c7e-02fc-4343-92a1-230061dfc5e0), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Foscarbidopa/foslevodopa generic labelers
37Risperidone generic labelers
Foscarbidopa/foslevodopaRisperidone
Labeled forParkinson's diseaseBipolar disorder, Schizophrenia
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$0.0368 per tablet 0.25 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?