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What the FDA labels say about taking them together

Fosaprepitant and triazolam

Fosaprepitant's FDA label of July 29, 2026 names triazolam in its drug interactions section; the triazolam label PlainMeds reads does not name fosaprepitant. The fosaprepitant label: “Clinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions.”

Check it at the source: the fosaprepitant FDA label on DailyMed (effective July 29, 2026, AVYXA Pharma, LLC); the triazolam FDA label on DailyMed (effective July 10, 2026, Mylan Pharmaceuticals Inc.).

What does the fosaprepitant label say about triazolam?

Fosaprepitant label, drug interactions

Clinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see ].

Source: FDA drug label (Focinvez, NDA216686), Steriscience Specialties Private Limited, effective March 30, 2026 (SPL set 18a60093-cec8-1b8c-e063-6394a90a8902), via openFDA

Source: FDA drug label (NAVITRUX), AVYXA Pharma, LLC, effective July 29, 2026 (SPL set a41b7c3a-1376-43a7-b5b9-6ba2eba1e169), via openFDA; the full label on DailyMed

What does the triazolam label say about fosaprepitant?

Triazolam's label (effective July 10, 2026) does not name fosaprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Triazolam), NDA017892 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective July 10, 2026 (SPL set 5add318e-11b9-42f8-b052-0d8cebb32fcf), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

16Fosaprepitant generic labelers
7Triazolam generic labelers
FosaprepitantTriazolam
Labeled forn/aInsomnia
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$0.308 per tablet 0.25 mg tablet
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?