What the FDA labels say about taking them together
Fosaprepitant and midazolam
Fosaprepitant's FDA label of July 29, 2026 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name fosaprepitant. The fosaprepitant label: “Clinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions.”
Check it at the source: the fosaprepitant FDA label on DailyMed (effective July 29, 2026, AVYXA Pharma, LLC); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the fosaprepitant label say about midazolam?
Fosaprepitant label, drug interactionsClinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see ].
Source: FDA drug label (Focinvez, NDA216686), Steriscience Specialties Private Limited, effective March 30, 2026 (SPL set 18a60093-cec8-1b8c-e063-6394a90a8902), via openFDA
Source: FDA drug label (NAVITRUX), AVYXA Pharma, LLC, effective July 29, 2026 (SPL set a41b7c3a-1376-43a7-b5b9-6ba2eba1e169), via openFDA; the full label on DailyMed
What does the midazolam label say about fosaprepitant?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name fosaprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosaprepitant | Midazolam | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once