What the FDA labels say about taking them together
Fosamprenavir and trazodone
Fosamprenavir's FDA label of September 15, 2023 names trazodone in its drug interactions section; the trazodone labels PlainMeds reads (2) do not name fosamprenavir. The fosamprenavir label: “Any paroxetine dose adjustment should be guided by clinical effect.”
Check it at the source: the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.); the trazodone FDA label on DailyMed (effective January 22, 2026, Zydus Pharmaceuticals USA Inc.).
What does the fosamprenavir label say about trazodone?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Antidepressant: Paroxetine, trazodone; Effect on Concentration of Amprenavir or Concomitant Drug: ↓ Paroxetine; Clinical Comment: Any paroxetine dose adjustment should be guided by clinical effect (tolerability and efficacy).
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
What does the trazodone label say about fosamprenavir?
Trazodone's label (effective January 22, 2026) and its 1 other brand-application label do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trazodone Hydrochloride), Zydus Pharmaceuticals USA Inc., effective January 22, 2026 (SPL set 704aebf9-2fff-4ef3-8323-9ff0d7f0ffd9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosamprenavir | Trazodone | |
|---|---|---|
| Labeled for | HIV | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0307 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once