What the FDA labels say about taking them together
Fosamprenavir and sirolimus
Fosamprenavir's FDA label of September 15, 2023 names sirolimus in its drug interactions section; the sirolimus labels PlainMeds reads (4) do not name fosamprenavir. The fosamprenavir label: “Therapeutic concentration monitoring is recommended for immunosuppressant agents.”
Check it at the source: the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the fosamprenavir label say about sirolimus?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Immunosuppressants: Cyclosporine, tacrolimus, sirolimus; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Immunosuppressants; Clinical Comment: Therapeutic concentration monitoring is recommended for immunosuppressant agents.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
What does the sirolimus label say about fosamprenavir?
Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosamprenavir | Sirolimus | |
|---|---|---|
| Labeled for | HIV | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once