What the FDA labels say about taking them together
Fosamprenavir and ranitidine
Fosamprenavir's FDA label of September 15, 2023 names ranitidine in its drug interactions section; the ranitidine label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Use with caution. Fosamprenavir may be less effective due to decreased amprenavir plasma concentrations.”
Check it at the source: the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.); the ranitidine FDA label on DailyMed (effective May 1, 2026, Amneal Pharmaceuticals of New York LLC).
What does the fosamprenavir label say about ranitidine?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Histamine H 2 -receptor antagonists: Cimetidine, famotidine, nizatidine, ranitidine; Effect on Concentration of Amprenavir or Concomitant Drug: Fosamprenavir: ↓ Amprenavir Fosamprenavir/ ritonavir: Interaction not evaluated; Clinical Comment: Use with caution. Fosamprenavir may be less effective due to decreased amprenavir plasma concentrations.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
What does the ranitidine label say about fosamprenavir?
Ranitidine's label (effective May 1, 2026) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ranitidine), Amneal Pharmaceuticals of New York LLC, effective May 1, 2026 (SPL set b38a3332-5c54-453f-aeb7-070f830955c2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosamprenavir | Ranitidine | |
|---|---|---|
| Labeled for | HIV | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once