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What the FDA labels say about taking them together

Fosamprenavir and nisoldipine

Fosamprenavir's FDA label of September 15, 2023 names nisoldipine in its drug interactions section; the nisoldipine label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Use with caution. Clinical monitoring of patients is recommended.”

Check it at the source: the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.); the nisoldipine FDA label on DailyMed (effective March 12, 2026, Covis Pharma US, Inc).

What does the fosamprenavir label say about nisoldipine?

Fosamprenavir label, drug interactions

Concomitant Drug Class/Drug Name: Calcium channel blockers: Diltiazem, felodipine, nifedipine, nicardipine, nimodipine, verapamil, amlodipine, nisoldipine, isradipine; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Calcium channel blockers; Clinical Comment: Use with caution. Clinical monitoring of patients is recommended.

Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed

What does the nisoldipine label say about fosamprenavir?

Nisoldipine's label (effective March 12, 2026) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Sular), NDA020356 (Azurity), as published by Covis Pharma US, Inc, effective March 12, 2026 (SPL set 589157fa-d129-4de3-be3d-e0e1c22c5873), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

2Fosamprenavir generic labelers
1Nisoldipine generic labelers
FosamprenavirNisoldipine
Labeled forHIVHigh blood pressure
Boxed warningNoNo
Pharmacy cost (NADAC)n/a$5.24 per tablet 34 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?