What the FDA labels say about taking them together
Fosamprenavir and lomitapide
Fosamprenavir's FDA label of September 15, 2023 names lomitapide in its contraindications section; the lomitapide label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Coadministration with lomitapide is contraindicated due to potential for markedly increased transaminases.”
Check it at the source: the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.); the lomitapide FDA label on DailyMed (effective March 30, 2026, Chiesi USA, Inc.).
What does the fosamprenavir label say about lomitapide?
Fosamprenavir label, contraindicationsLomitapide, lovastatin, simvastatin o Non-nucleoside reverse transcriptase inhibitor: Delavirdine o PDE5 inhibitor:
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Other lipid modifying agents: Lomitapide; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Lomitapide; Clinical Comment: Coadministration with lomitapide is contraindicated due to potential for markedly increased transaminases.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
What does the lomitapide label say about fosamprenavir?
Lomitapide's label (effective March 30, 2026) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Juxtapid), Chiesi USA, Inc., effective March 30, 2026 (SPL set 61a0be9d-ee58-43e0-b5cb-141011835081), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosamprenavir | Lomitapide | |
|---|---|---|
| Labeled for | HIV | High cholesterol |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once