What the FDA labels say about taking them together
Fosamprenavir and imipramine
Fosamprenavir's FDA label of September 15, 2023 names imipramine in its drug interactions section; the imipramine label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Therapeutic concentration monitoring is recommended for tricyclic antidepressants.”
Check it at the source: the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.); the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC).
What does the fosamprenavir label say about imipramine?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Tricyclic antidepressants: Amitriptyline, imipramine; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Tricyclics; Clinical Comment: Therapeutic concentration monitoring is recommended for tricyclic antidepressants.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
What does the imipramine label say about fosamprenavir?
Imipramine's label (effective August 11, 2026) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fosamprenavir | Imipramine | |
|---|---|---|
| Labeled for | HIV | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0698 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once