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What the FDA labels say about taking them together

Follitropin alfa and progesterone

Follitropin alfa's FDA label of September 2, 2025 names progesterone in its warnings and precautions section; the progesterone labels PlainMeds reads (3) do not name follitropin alfa. The follitropin alfa label: “Direct or indirect indices of progesterone production: Urinary or serum luteinizing hormone (LH) rise A rise in basal body temperature Increase in serum progesterone Menstruation following a shift in basal body …”

Check it at the source: the follitropin alfa FDA label on DailyMed (effective September 2, 2025); the progesterone FDA label on DailyMed (effective July 23, 2026, Acertis Pharmaceuticals, LLC).

What does the follitropin alfa label say about progesterone?

Follitropin alfa label, warnings and precautions

Direct or indirect indices of progesterone production: Urinary or serum luteinizing hormone (LH) rise A rise in basal body temperature Increase in serum progesterone Menstruation following a shift in basal body temperature Sonographic evidence of ovulation:

Source: FDA drug label (Gonal-f), EMD Serono, Inc., effective September 2, 2025 (SPL set ae85b9c3-e7eb-4981-a5d9-346050e8f189), via openFDA; the full label on DailyMed

What does the progesterone label say about follitropin alfa?

Progesterone's label (effective July 23, 2026) and its 2 other brand-application labels do not name follitropin alfa in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Prometrium), Acertis Pharmaceuticals, LLC, effective July 23, 2026 (SPL set 1cf237ff-c4f8-4faa-a7aa-77599c856889), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Follitropin alfa generic labelers
25Progesterone generic labelers
Follitropin alfaProgesterone
Labeled forn/an/a
Boxed warningNoNo
Pharmacy cost (NADAC)n/a$0.229 per capsule 100 mg capsule
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?