What the FDA labels say about taking them together
Folic acid and nitrous oxide
Folic acid's FDA label (Folic Acid) of February 11, 2026 names nitrous oxide in its drug interactions section; the nitrous oxide labels PlainMeds reads (4) do not name folic acid. The folic acid label: “Nitrous oxide indirectly decreases folate activity by inactivating vitamin B12 and downstream methylation pathways, while oral contraceptives increase folate turnover and urinary loss.”
Check it at the source: the folic acid FDA label on DailyMed (effective July 24, 2026, Rising Pharma Holdings, Inc.); the nitrous oxide FDA label on DailyMed (effective December 2, 2025, Machine & Welding Supply Company dba Arc3 Gases South).
What does the folic acid label say about nitrous oxide?
Folic Acid label (Ayurax, LLC, February 11, 2026), drug interactionsNitrous oxide indirectly decreases folate activity by inactivating vitamin B12 and downstream methylation pathways, while oral contraceptives increase folate turnover and urinary loss.
Source: FDA drug label (Folic Acid, NDA216395), Ayurax, LLC, effective February 11, 2026 (SPL set 96618bf8-6c03-4df3-9896-b7ef27ca392a), via openFDA
Source: FDA drug label (Folic Acid), Rising Pharma Holdings, Inc., effective July 24, 2026 (SPL set 0baa10dd-6d1d-4946-8236-566451132da3), via openFDA; the full label on DailyMed
What does the nitrous oxide label say about folic acid?
Nitrous oxide's label (effective December 2, 2025) and its 3 other brand-application labels do not name folic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nitrous Oxide), Machine & Welding Supply Company dba Arc3 Gases South, effective December 2, 2025 (SPL set a5070767-c36a-4131-aa09-1bccfa24aa71), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Folic acid | Nitrous oxide | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0201 per tablet 1 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once