What the FDA labels say about taking them together
Fluvoxamine and mexiletine
Fluvoxamine's FDA label of June 27, 2026 names mexiletine in its warnings and precautions section, and mexiletine's label names fluvoxamine too. The fluvoxamine label: “The clearance of mexiletine was reduced by 38% following coadministration with fluvoxamine compared to mexiletine alone.”
Check it at the source: the fluvoxamine FDA label on DailyMed (effective June 27, 2026, Zydus Pharmaceuticals USA Inc.); the mexiletine FDA label on DailyMed (effective May 14, 2026, Macleods Pharmaceuticals Limited).
What does the fluvoxamine label say about mexiletine?
Fluvoxamine label, warnings and precautionsThe clearance of mexiletine was reduced by 38% following coadministration with fluvoxamine compared to mexiletine alone.
Source: FDA drug label (Fluvoxamine maleate extended-release), Zydus Pharmaceuticals USA Inc., effective June 27, 2026 (SPL set 6c71d4f6-54b5-4d3a-8d2f-b7773c92c32e), via openFDA; the full label on DailyMed
What does the mexiletine label say about fluvoxamine?
Mexiletine label, drug interactionsIn a formal, single-dose interaction study (n = 6 males) the clearance of mexiletine was decreased by 38% following the coadministration of fluvoxamine, an inhibitor of CYP1A2.
Source: FDA drug label (Mexiletine Hydrochloride), Macleods Pharmaceuticals Limited, effective May 14, 2026 (SPL set a61a07f6-0b48-4dcd-ad42-5d90f6e69ab1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvoxamine | Mexiletine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $4.08 per capsule 100 mg capsule | $0.222 per capsule 150 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once