What the FDA labels say about taking them together
Fluvoxamine and lidocaine
Lidocaine's FDA label (Lidocaine Hydrochloride And Dextrose) of February 20, 2026 names fluvoxamine in its drug interactions section; the fluvoxamine labels PlainMeds reads (2) do not name lidocaine. The lidocaine label: “Concomitant use of lidocaine at steady-state concentrations of the CYP1A2 inhibitor fluvoxamine increases intravenous lidocaine plasma AUC and C max by 71% and 22%, and decreases MEGX AUC and C max by 54% and 65%.”
Check it at the source: the fluvoxamine FDA label on DailyMed (effective June 27, 2026, Zydus Pharmaceuticals USA Inc.); the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC).
What does the fluvoxamine label say about lidocaine?
Fluvoxamine's label (effective June 27, 2026) and its 1 other brand-application label do not name lidocaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvoxamine maleate extended-release), Zydus Pharmaceuticals USA Inc., effective June 27, 2026 (SPL set 6c71d4f6-54b5-4d3a-8d2f-b7773c92c32e), via openFDA; the full label on DailyMed
What does the lidocaine label say about fluvoxamine?
Lidocaine Hydrochloride And Dextrose label (Baxter Healthcare Corporation, February 20, 2026), drug interactionsConcomitant use of lidocaine at steady-state concentrations of the CYP1A2 inhibitor fluvoxamine increases intravenous lidocaine plasma AUC and C max by 71% and 22%, and decreases MEGX AUC and C max by 54% and 65%.
Source: FDA drug label (Lidocaine Hydrochloride And Dextrose, NDA018461), Baxter Healthcare Corporation, effective February 20, 2026 (SPL set f21512ea-c7c3-4766-b976-b2c0b5616bf0), via openFDA
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvoxamine | Lidocaine | |
|---|---|---|
| Labeled for | n/a | Pain |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $4.08 per capsule 100 mg capsule | $0.154 per gram 5% ointment |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once