What the FDA labels say about taking them together
Fluvastatin and spironolactone
Fluvastatin's FDA label of April 21, 2025 names spironolactone in its warnings and precautions section; the spironolactone labels PlainMeds reads (2) do not name fluvastatin. The fluvastatin label: “Caution should be exercised if a statin or other agent used to lower cholesterol levels is administered to patients receiving other drugs that may decrease the levels of endogenous steroid hormones.”
Check it at the source: the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.); the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc).
What does the fluvastatin label say about spironolactone?
Fluvastatin label, warnings and precautionsCaution should be exercised if a statin or other agent used to lower cholesterol levels is administered to patients receiving other drugs (e.g., ketoconazole, spironolactone, cimetidine) that may decrease the levels of endogenous steroid hormones.
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
What does the spironolactone label say about fluvastatin?
Spironolactone's label (effective November 28, 2025) and its 1 other brand-application label do not name fluvastatin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvastatin | Spironolactone | |
|---|---|---|
| Labeled for | High cholesterol | Heart failure, Edema (fluid retention), High blood pressure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.88 per tablet 80 mg tablet | $0.0426 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once