What the FDA labels say about taking them together
Fluvastatin and ketoconazole
Fluvastatin's FDA label of April 21, 2025 names ketoconazole in its warnings and precautions section; the ketoconazole label PlainMeds reads does not name fluvastatin. The fluvastatin label: “Caution should be exercised if a statin or other agent used to lower cholesterol levels is administered to patients receiving other drugs that may decrease the levels of endogenous steroid hormones.”
Check it at the source: the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the fluvastatin label say about ketoconazole?
Fluvastatin label, warnings and precautionsCaution should be exercised if a statin or other agent used to lower cholesterol levels is administered to patients receiving other drugs (e.g., ketoconazole, spironolactone, cimetidine) that may decrease the levels of endogenous steroid hormones.
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
What does the ketoconazole label say about fluvastatin?
Ketoconazole's label (effective January 28, 2026) does not name fluvastatin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvastatin | Ketoconazole | |
|---|---|---|
| Labeled for | High cholesterol | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.88 per tablet 80 mg tablet | $0.249 per gram 2% cream |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once