fluticasone/vilanterol vs ketoconazole
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Side-by-side comparison of fluticasone/vilanterol and ketoconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7 DRUG INTERACTIONS • Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol. Caution should be exercised when considering the coadministration of BREO ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors [see Warnings and Precautions ( 5.9 ), Clinical Pharmacology ( 12.3 )] .
Breo Ellipta
Nizoral
Breo Ellipta is a medicine that contains a corticosteroid and a long-acting beta-agonist. It is used to help control symptoms of COPD and asthma.
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Breo Ellipta is used to treat COPD in adults. It is also used to treat asthma in people ages 5 and older. This medicine helps to improve your breathing by reducing inflammation and opening airways.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Breo Ellipta contains two medicines. Fluticasone furoate reduces inflammation in the lungs. Vilanterol helps to relax the muscles around your airways, making it easier to breathe.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
- • Sore throat
- • Upper respiratory infection
- • Headache
- • Mouth infection (oral candidiasis)
- • Back pain
No common side effects listed.
No adverse event reports.
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
LABA medicines such as vilanterol, when used alone, increase the risk of asthma-related death. Breo Ellipta should not be used to treat sudden breathing problems. Do not use Breo Ellipta with other medicines that contain a LABA.
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if Breo Ellipta will harm your unborn baby. Breo Ellipta should be used during late pregnancy only if the potential benefit justifies the potential risk.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
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How to Read This fluticasone/vilanterol vs ketoconazole Comparison
fluticasone/vilanterol is classified in the Corticosteroid / Long-Acting Beta-2 Agonist Combination drug class, while ketoconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluticasone/vilanterol has 0 submissions while ketoconazole has 4,227. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to ketoconazole interferes with how your body processes the inhaler, which can result in higher-than-normal levels of the medicine in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluticasone/vilanterol or ketoconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.