What the FDA labels say about taking them together
Fluoxetine and procainamide
Fluoxetine's FDA label of January 8, 2026 names procainamide in its drug interactions section; the procainamide label PlainMeds reads does not name fluoxetine.
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the procainamide FDA label on DailyMed (effective February 17, 2025, Caplin Steriles Limited).
What does the fluoxetine label say about procainamide?
Fluoxetine label, drug interactionsClass 1A antiarrhythmic medications (e.g., quinidine, procainamide);
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the procainamide label say about fluoxetine?
Procainamide's label (effective February 17, 2025) does not name fluoxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Procainamide Hydrochloride), Caplin Steriles Limited, effective February 17, 2025 (SPL set fcaa5e9a-3c8a-4796-aa87-626268b6cf60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Procainamide | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once