What the FDA labels say about taking them together
Fluoxetine and paroxetine
Paroxetine's FDA label (Brisdelle) of April 28, 2025 names fluoxetine in its drug interactions section; fluoxetine's label does not name paroxetine itself but warns about its class (serotonin reuptake inhibitors).
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the fluoxetine label say about paroxetine?
Fluoxetine's label does not name paroxetine itself; it warns about its class (serotonin reuptake inhibitors):
Fluoxetine label, warnings and precautionsBleeding reactions related to SNRIs and SSRIs use have ranged from ecchymoses, hematomas, epistaxis, and petechiae to life-threatening hemorrhages.
Fluoxetine label, warnings and precautionsSelective serotonin reuptake inhibitors (SSRIs), including PROZAC, can precipitate serotonin syndrome, a potentially life-threatening condition.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the paroxetine label say about fluoxetine?
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsUse caution with concomitant use of BRISDELLE with other drugs that are metabolized by CYP2D6, including nortriptyline, amitriptyline, imipramine, desipramine, fluoxetine, phenothiazines, risperidone, and Type 1C antiarrhythmics (e.g., propafenone, flecainide, and encainide).
Source: FDA drug label (Brisdelle, NDA204516), Legacy Pharma USA, Inc., effective April 28, 2025 (SPL set 502311b3-b617-4cbd-a3ab-a60f2c62880a), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Paroxetine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | Depression, Anxiety, Menopause symptoms |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once