What the FDA labels say about taking them together
Fluoxetine and metoclopramide
Metoclopramide's FDA label of May 18, 2026 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name metoclopramide. The metoclopramide label: “Strong CYP2D6 inhibitors: See Full Prescribing Information for recommended dosage reductions.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the metoclopramide FDA label on DailyMed (effective May 18, 2026, ANI Pharmaceuticals, Inc.).
What does the fluoxetine label say about metoclopramide?
Fluoxetine's label (effective January 8, 2026) does not name metoclopramide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the metoclopramide label say about fluoxetine?
Metoclopramide label, drug interactionsStrong CYP2D6 inhibitors (e.g., quinidine, bupropion, fluoxetine, and paroxetine): See Full Prescribing Information for recommended dosage reductions.
Gimoti label (Evoke Pharma, Inc., February 20, 2026), drug interactionsExamples; quinidine, bupropion, fluoxetine, and paroxetine
Source: FDA drug label (Gimoti, NDA209388), Evoke Pharma, Inc., effective February 20, 2026 (SPL set 95269b1f-779c-4ca0-9f86-e74e677f9900), via openFDA
Source: FDA drug label (Metoclopramide), NDA017854 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective May 18, 2026 (SPL set 797aad80-0597-42f8-99d5-39de180c3b5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Metoclopramide | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | Acid reflux and ulcers, Nausea and vomiting |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $0.0439 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once