What the FDA labels say about taking them together
Flecainide and fluoxetine
Fluoxetine's FDA label of January 8, 2026 names flecainide in its drug interactions section; the flecainide label PlainMeds reads does not name fluoxetine.
Check it at the source: the flecainide FDA label on DailyMed (effective June 11, 2026, Amneal Pharmaceuticals of New York LLC); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the flecainide label say about fluoxetine?
Flecainide's label (effective June 11, 2026) does not name fluoxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Flecainide Acetate), Amneal Pharmaceuticals of New York LLC, effective June 11, 2026 (SPL set ee9595d5-08a1-4529-9215-ddc3c7f929c4), via openFDA; the full label on DailyMed
What does the fluoxetine label say about flecainide?
Fluoxetine label, drug interactionsCoadministration of fluoxetine with other drugs that are metabolized by CYP2D6, including certain antidepressants (e.g., TCAs), antipsychotics (e.g., phenothiazines and most atypicals), and antiarrhythmics (e.g., propafenone, flecainide, and others) should be approached with caution.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Flecainide | Fluoxetine | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety, Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.171 per tablet 100 mg tablet | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once